Minimal enteral nutrient requirements for intestinal growth in neonatal piglets: how much is enough?

Minimal enteral nutrient requirements for intestinal growth in neonatal piglets: how much is enough?

BACKGROUND Parenterally nourished preterm infants commonly receive minimal enteral feedings, the aim being to enhance intestinal function. Whether this regimen increases intestinal growth has not been established. OBJECTIVE Our objective was to determine the minimal enteral nutrient intakes necessary to stimulate and to normalize neonatal intestinal growth. METHODS Intestinal growth and cel...

Neonatal workforce: how much is enough?

How much vancomycin dose is enough for the MRSA infection in pediatric patients with various degrees of renal function?

Today, an increase in vancomycin dose has been proposed to ensure efficacy. However, the risk of nephrotoxicity will increase with the dose. This study was aimed at evaluating the dosage regimens of vancomycin in pediatric patients based on pharmacokinetics/pharmacodynamics (PK/PD) and to optimize dosage individualization. Population pharmacokinetics analysis was performed on 155 Chinese childr...

Escalation: How Much is Enough?

often the subject of fierce debate. Cost increases are determined by dynamic relationships between many factors, including acts of nature, interest rates, oil prices, global commodity markets, wars, wage rates, and the overall health of the economy, as well as supply and demand for the required goods or services. How much escalation is enough? Are the recent price increases temporary aberration...

How much REST is enough?

Recent papers published in Nature by Guardavaccaro et al. and Westbrook et al. describe a nexus of two masters of negative regulation of protein levels. Both of these studies establish that the transcriptional repressor REST/NRSF is regulated by the highly versatile ubiquitin protein ligase (E3) SCF(beta-TrCP), adding a new dimension to the relationship between the ubiquitin-proteasome system a...